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lattice-light-sheet microscopy

NOT Open Access | Illuminating Plasmodium invasion by lattice-light-sheet microscopy

August 4, 2021 - 12:05 -- NOT Open Access
Author(s): 
Ganter M, Frischknecht F
Reference: 
Trends Parasitol. 2021 Jul 28:S1471-4922(21)00173-2

Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution.Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite-host cell interface.

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