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Plasmodium vivax Infection Alters Mitochondrial Metabolism in Human Monocytes

July 28, 2021 - 14:23 -- Open Access
Diniz SQ, Teixeira-Carvalho A, Figueiredo MM, Costa PAC, Rocha BC, Martins-Filho OA, Gonçalves R, Pereira DB, Tada MS, Oliveira F, Gazzinelli RT, Antonelli LRDV
mBio. 2021 Jul 27:e0124721

Monocytes play an important role in the host defense against Plasmodium vivax as the main source of inflammatory cytokines and mitochondrial reactive oxygen species (mROS). Here, we show that monocyte metabolism is altered during human P. vivax malaria, with mitochondria playing a major function in this switch. The process involves a reprograming in which the cells increase glucose uptake and produce ATP via glycolysis instead of oxidative phosphorylation.

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