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Plasmodium vivax binds host CD98hc (SLC3A2) to enter immature red blood cells

July 28, 2021 - 13:59 -- Open Access
Malleret B, El Sahili A, Rénia L, et al.
Nat Microbiol 6, 991–999 (2021)

More than one-third of the world's population is exposed to Plasmodium vivax malaria, mainly in Asia1. P. vivax preferentially invades reticulocytes (immature red blood cells)2-4. Previous work has identified 11 parasite proteins involved in reticulocyte invasion, including erythrocyte binding protein 2 (ref. 5) and the reticulocyte-binding proteins (PvRBPs)6-10.

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