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phospholipid flippase

A malaria parasite phospholipid flippase safeguards midgut traversal of ookinetes for mosquito transmission

July 28, 2021 - 12:51 -- Open Access
Author(s): 
Yang Z, Shi Y, Cui H, Yang S, Gao H, Yuan J
Reference: 
Sci Adv. 2021 Jul 23;7(30):eabf6015

Mosquito midgut epithelium traversal is essential for malaria parasite transmission. Phospholipid flippases are eukaryotic type 4 P-type adenosine triphosphatases (P4-ATPases), which, in association with CDC50, translocate phospholipids across the membrane lipid bilayers. In this study, we investigated the function of a putative P4-ATPase, ATP7, from the rodent malaria parasite Plasmodium yoelii Disruption of ATP7 blocks the parasite infection of mosquitoes.

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