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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

July 13, 2021 - 15:03 -- Open Access
Xu K, Wang Y, Kwong PD, et al.
Nat Commun. 2021 Jul 9;12(1):4226

RIFIN, a large family of Plasmodium variant surface antigens, plays a crucial role in malaria pathogenesis by mediating immune suppression through activation of inhibitory receptors such as LAIR1, and antibodies with LAIR1 inserts have been identified that bind infected erythrocytes through RIFIN. However, details of RIFIN-mediated LAIR1 recognition and receptor activation have been unclear.

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