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PfDXR

NOT Open Access | Natural products for treatment of Plasmodium falciparum malaria: An integrated computational approach

July 7, 2021 - 15:03 -- NOT Open Access
Author(s): 
Muhseen ZT, Hameed AR, Al-Bhadly O, Ahmad S, Li G
Reference: 
Comput Biol Med. 2021 Jul;134:104415

Malaria is a life-threatening infectious disease with an estimated 229 million cases in the year 2019 worldwide. Plasmodium falciparum 1-deoxy-d-xylulose-5-phosphate reductoisomerase (PfDXR) is one of the key enzymes in the biosynthetic pathway of isoprenoid, (required for parasite growth and survival) and considered as an attractive target for designing anti-malarial drugs.

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