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NOT Open Access | Synthesis and structure-activity relationships of new chiral spiro-beta-lactams highly active against HIV-1 and Plasmodium

July 6, 2021 - 13:06 -- NOT Open Access
Alves NG, Bártolo I, Pinho E Melo TMVD, et al.
Eur J Med Chem. 2021 Jul 5;219:113439

The synthesis and antimicrobial activity of new spiro-β-lactams is reported. The design of the new molecules was based on the structural modulation of two previously identified lead spiro-penicillanates with dual activity against HIV and Plasmodium.

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