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IgA

NOT Open Access | Functional human IgA targets a conserved site on malaria sporozoites

June 29, 2021 - 14:02 -- NOT Open Access
Author(s): 
Tan J, Cho H, Crompton PD, et al.
Reference: 
Sci Transl Med. 2021 Jun 23;13(599):eabg2344

Immunoglobulin (Ig)A antibodies play a critical role in protection against mucosal pathogens. However, the role of serum IgA in immunity to nonmucosal pathogens, such as Plasmodium falciparum, is poorly characterized, despite being the second most abundant isotype in blood after IgG. Here, we investigated the circulating IgA response in humans to P. falciparum sporozoites that are injected into the skin by mosquitoes and migrate to the liver via the bloodstream to initiate malaria infection. We found that circulating IgA was induced in three independent sporozoite-exposed cohorts: individuals living in an endemic region in Mali, malaria-naïve individuals immunized intravenously with three large doses of irradiated sporozoites, and malaria-naïve individuals exposed to a single controlled mosquito bite infection.

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