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M17

Mapping the substrate specificity of the Plasmodium M1 and M17 aminopeptidases

June 23, 2021 - 13:27 -- Open Access
Author(s): 
Malcolm TR, Swiderska KW, Hayes BK, Webb CT, Drag M, Drinkwater N, McGowan S
Reference: 
Biochem J. 2021 Jun 16:BCJ20210172

During malarial infection, Plasmodium parasites digest human hemoglobin to obtain free amino acids for protein production and maintenance of osmotic pressure. The Plasmodium M1 and M17 aminopeptidases are both postulated to have an essential role in the terminal stages of the hemoglobin digestion process and are validated drug targets for the design of new dual-target anti-malarial compounds.

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