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Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique

August 10, 2021 - 17:36 -- Open Access
Marti-Soler H, Máquina M, Opiyo M, Alafo C, Sherrard-Smith E, Malheia A, Cuamba N, Sacoor C, Rabinovich R, Aide P, Saúte F, Paaijmans K
PLoS One. 2021 Aug 5;16(8):e0248604

Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™ 50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018-2019 malaria season.

Malaria prevention knowledge, attitudes, and practices in Zambezia Province, Mozambique

July 7, 2021 - 07:58 -- Open Access
Liliana de Sousa Pinto, Jorge A. H. Arroz, Maria do Rosário O. Martins, Zulmira Hartz, Nuria Negrao, Victor Muchanga, Amadeu Cossa and Rose Zulliger
Malaria Journal 2021 20:293, 30 June 2021

In Mozambique, socio-economic and cultural factors influence the wide adoption of disease preventive measures that are relevant for malaria control strategies to promote early recognition of disease, prompt seeking of medical care, sleeping under insecticide-treated nets (ITNs), and taking intermittent preventive treatment for pregnant women. However, there is a critical information gap regarding previous and ongoing malaria social and behavioural change (SBC) interventions. The aim of this study is to assess the knowledge, attitudes, practices of beneficiaries of SBC interventions.

NOT Open Access | Utilization of a local 'Malaria Post' indicates that carers from a village in Mozambique respond appropriately to malaria attacks

June 30, 2021 - 09:33 -- NOT Open Access
Charlwood JD, Tomás EVE, Enosse S, Saija SP, Sahlholdt J, Filemon L, Kampango A
Acta Trop. 2021 Jun 23:106017

As malaria elimination becomes a possibility the focus of interventions changes from vector control to disease control. It is important that treatment occurs early during an infection, in order for it to be efficacious, especially at the population level. The time between the onset of symptoms and treatment seeking is, therefore, crucial. Following a census and an oral autopsy survey of the inhabitants of Furvela, a village in southern Mozambique, a malaria post (MP) where malaria was diagnosed and treated was established in 2001.

Not Open Access | The short-term impact of a malaria elimination initiative in Southern Mozambique: Application of the synthetic control method to routine surveillance data

June 15, 2021 - 14:40 -- NOT Open Access
Thomas R, Cirera L, Brew J, Saúte F, Sicuri E
Health Econ. 2021 Jun 8

In public health epidemiology, quasi-experimental methods are widely used to estimate the causal impacts of interventions. In this paper, we demonstrate the contribution the synthetic control method (SCM) can make in evaluating public health interventions, when routine surveillance data are available and the validity of other quasi-experimental approaches may be in question.

Accuracy of verbal autopsy, clinical data and minimally invasive autopsy in the evaluation of malaria-specific mortality: an observational study

June 9, 2021 - 14:19 -- Open Access
Rakislova N, Jordao D, Ordi J, et al.
BMJ Glob Health. 2021 Jun;6(6):e005218

Global malaria mortality estimates are hindered by the low reliability of the verbal autopsy (VA) and the clinical records, the most common sources of information used to estimate malaria-specific mortality. We aimed to determine the accuracy of these tools, as well as of the minimally invasive autopsy (MIA), a needle-based postmortem sampling method, to identify malaria-specific mortality in a large series of deceased patients from Mozambique, using complete autopsy as the gold standard.

Factors associated with use of insecticide-treated net for malaria prevention in Manica District, Mozambique: a community-based cross-sectional survey

April 28, 2021 - 15:50 -- Open Access
Julia Scott, Mufaro Kanyangarara, Abel Nhama, Eusebio Macete, William John Moss and Francisco Saute
Malaria Journal 2021 20:200, 27 April 2021

Insecticide-treated net (ITN) use is crucial for preventing malaria infection. Despite significant improvements in ITN access and use over the past two decades, many malaria-endemic countries in sub-Saharan Africa have not yet reached global targets for universal coverage of ITNs. To reduce the gaps in ITN use, it is important to understand the factors associated with ITN use. The goal of this analysis was to determine the factors associated with ITN use in Manica District, Mozambique.

Community acceptability to antimalarial mass drug administrations in Magude district, Southern Mozambique: A mixed methods study

March 24, 2021 - 14:03 -- Open Access
Galatas B, Nhantumbo H, Munguambe K, et al.
PLoS One. 2021 Mar 23;16(3):e0249080

This study aimed to capture the acceptability prior to, during and after the implementation of the first year of MDA rounds conducted under the Magude project, a malaria elimination project in southern Mozambique.

Cost and cost-effectiveness of indoor residual spraying with pirimiphos-methyl in a high malaria transmission district of Mozambique with high access to standard insecticide-treated nets

March 13, 2021 - 17:09 -- Open Access
Alonso S, Chaccour CJ, Wagman J, Candrinho B, Muthoni R, Saifodine A, Saute F, Robertson M, Zulliger R
Malar J. 2021 Mar 10;20(1):143

As malaria cases increase in some of the highest burden countries, more strategic deployment of new and proven interventions must be evaluated to meet global malaria reduction goals.


The cost and cost-effectiveness of indoor residual spraying (IRS) with pirimiphos-methyl (Actellic®300 CS) were assessed in a high transmission district (Mopeia) with high access to pyrethroid insecticide-treated nets (ITNs), compared to ITNs alone. The major mosquito vectors in the area were susceptible to primiphos-methyl, but resistant to pyrethoids. A decision analysis approach was followed to conduct deterministic and probabilistic sensitivity analyses in a theoretical cohort of 10,000 children under five years of age (U5) and 10,000 individuals of all ages, separately. Model parameters and distributions were based on prospectively collected cost and epidemiological data from a cluster-randomized control trial and a literature review. The primary analysis used health facility-malaria incidence, while community cohort incidence and cross-sectional prevalence rates were used in sensitivity analyses. Lifetime costs, malaria cases, deaths and disability-adjusted life-years (DALYs) were calculated to determine the incremental costs per DALY averted through IRS.

Incremental impact on malaria incidence following indoor residual spraying in a highly endemic area with high standard ITN access in Mozambique: results from a cluster‐randomized study

February 11, 2021 - 09:37 -- Open Access
Carlos Chaccour, Rose Zulliger, Francisco Saute, et al.
Malaria Journal 2021 20:84, 10 February 2021

Attaining the goal of reducing the global malaria burden is threatened by recent setbacks in maintaining the effectiveness of vector control interventions partly due to the emergence of pyrethroid resistant vectors. One potential strategy to address these setbacks could be combining indoor residual spraying (IRS) with non-pyrethroids and standard insecticide-treated nets (ITNs). This study aimed to provide evidence on the incremental epidemiological benefit of using third-generation IRS product in a highly endemic area with high ITN ownership.

Biomarkers to distinguish bacterial from viral pediatric clinical pneumonia in a malaria endemic setting

February 9, 2021 - 09:52 -- Open Access
Gillette MA, Mani DR, Wirth DF, et al.
Clin Infect Dis. 2021 Feb 3:ciaa1843

Differential etiologies of pediatric acute febrile respiratory illness pose challenges for all populations globally but especially in malaria-endemic settings because the pathogens responsible overlap in clinical presentation and frequently occur together. Rapid identification of bacterial pneumonia with high quality diagnostic tools would enable appropriate, point of care antibiotic treatment. Current diagnostics are insufficient, and the discovery and development of new tools is needed. We report a unique biomarker signature identified in blood samples to accomplish this.


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