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Molecular surveillance for polymorphisms associated with artemisinin-based combination therapy resistance in Plasmodium falciparum isolates collected in Mozambique, 2018

October 23, 2021 - 18:35 -- Open Access
Arlindo Chidimatembue, Samaly S. Svigel, Eusébio Macete, et al.
Malaria Journal 2021 20:398, 12 October 2021

Due to the threat of emerging anti-malarial resistance, the World Health Organization recommends incorporating surveillance for molecular markers of anti-malarial resistance into routine therapeutic efficacy studies (TESs). In 2018, a TES of artemether-lumefantrine (AL) and artesunate-amodiaquine (ASAQ) was conducted in Mozambique, and the prevalence of polymorphisms in the pfk13, pfcrt, and pfmdr1 genes associated with drug resistance was investigated.

In vivo efficacy and safety of artemether–lumefantrine and amodiaquine–artesunate for uncomplicated Plasmodium falciparum malaria in Mozambique, 2018

October 23, 2021 - 18:01 -- Open Access
Abel Nhama, Lídia Nhamússua, Pedro Aide, et al.
Malaria Journal 2021 20:390, 2 October 2021

Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether–lumefantrine (AL) and amodiaquine–artesunate (AS–AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy study was conducted.

Assessment of the Feasibility, Acceptability, and Impact of Implementing Seasonal Malaria Chemoprevention in Nampula Province, Mozambique: Protocol for a Hybrid Effectiveness-Implementation Study

September 23, 2021 - 09:19 -- Open Access
Wharton-Smith A, Baker K, Candrinho B, et al.
JMIR Res Protoc. 2021 Sep 15;10(9):e27855

Malaria is a significant cause of morbidity and mortality in children aged under 5 years in Mozambique. The World Health Organization recommends seasonal malaria chemoprevention (SMC), the administration of four monthly courses of sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ), to children aged 3-59 months during rainy season. However, as resistance to SP is widespread in East and Southern Africa, SMC has so far only been implemented across the Sahel in West Africa.

Effect of wall type, delayed mortality and mosquito age on the residual efficacy of a clothianidin-based indoor residual spray formulation (SumiShield™ 50WG) in southern Mozambique

August 10, 2021 - 17:36 -- Open Access
Marti-Soler H, Máquina M, Opiyo M, Alafo C, Sherrard-Smith E, Malheia A, Cuamba N, Sacoor C, Rabinovich R, Aide P, Saúte F, Paaijmans K
PLoS One. 2021 Aug 5;16(8):e0248604

Indoor residual spraying (IRS) is one of the main malaria vector control strategies in Mozambique alongside the distribution of insecticide treated nets. As part of the national insecticide resistance management strategy, Mozambique introduced SumiShield™ 50WG, a third generation IRS product, in 2018. Its residual efficacy was assessed in southern Mozambique during the 2018-2019 malaria season.

Malaria prevention knowledge, attitudes, and practices in Zambezia Province, Mozambique

July 7, 2021 - 07:58 -- Open Access
Liliana de Sousa Pinto, Jorge A. H. Arroz, Maria do Rosário O. Martins, Zulmira Hartz, Nuria Negrao, Victor Muchanga, Amadeu Cossa and Rose Zulliger
Malaria Journal 2021 20:293, 30 June 2021

In Mozambique, socio-economic and cultural factors influence the wide adoption of disease preventive measures that are relevant for malaria control strategies to promote early recognition of disease, prompt seeking of medical care, sleeping under insecticide-treated nets (ITNs), and taking intermittent preventive treatment for pregnant women. However, there is a critical information gap regarding previous and ongoing malaria social and behavioural change (SBC) interventions. The aim of this study is to assess the knowledge, attitudes, practices of beneficiaries of SBC interventions.

NOT Open Access | Utilization of a local 'Malaria Post' indicates that carers from a village in Mozambique respond appropriately to malaria attacks

June 30, 2021 - 09:33 -- NOT Open Access
Charlwood JD, Tomás EVE, Enosse S, Saija SP, Sahlholdt J, Filemon L, Kampango A
Acta Trop. 2021 Jun 23:106017

As malaria elimination becomes a possibility the focus of interventions changes from vector control to disease control. It is important that treatment occurs early during an infection, in order for it to be efficacious, especially at the population level. The time between the onset of symptoms and treatment seeking is, therefore, crucial. Following a census and an oral autopsy survey of the inhabitants of Furvela, a village in southern Mozambique, a malaria post (MP) where malaria was diagnosed and treated was established in 2001.

Not Open Access | The short-term impact of a malaria elimination initiative in Southern Mozambique: Application of the synthetic control method to routine surveillance data

June 15, 2021 - 14:40 -- NOT Open Access
Thomas R, Cirera L, Brew J, Saúte F, Sicuri E
Health Econ. 2021 Jun 8

In public health epidemiology, quasi-experimental methods are widely used to estimate the causal impacts of interventions. In this paper, we demonstrate the contribution the synthetic control method (SCM) can make in evaluating public health interventions, when routine surveillance data are available and the validity of other quasi-experimental approaches may be in question.

Accuracy of verbal autopsy, clinical data and minimally invasive autopsy in the evaluation of malaria-specific mortality: an observational study

June 9, 2021 - 14:19 -- Open Access
Rakislova N, Jordao D, Ordi J, et al.
BMJ Glob Health. 2021 Jun;6(6):e005218

Global malaria mortality estimates are hindered by the low reliability of the verbal autopsy (VA) and the clinical records, the most common sources of information used to estimate malaria-specific mortality. We aimed to determine the accuracy of these tools, as well as of the minimally invasive autopsy (MIA), a needle-based postmortem sampling method, to identify malaria-specific mortality in a large series of deceased patients from Mozambique, using complete autopsy as the gold standard.

Factors associated with use of insecticide-treated net for malaria prevention in Manica District, Mozambique: a community-based cross-sectional survey

April 28, 2021 - 15:50 -- Open Access
Julia Scott, Mufaro Kanyangarara, Abel Nhama, Eusebio Macete, William John Moss and Francisco Saute
Malaria Journal 2021 20:200, 27 April 2021

Insecticide-treated net (ITN) use is crucial for preventing malaria infection. Despite significant improvements in ITN access and use over the past two decades, many malaria-endemic countries in sub-Saharan Africa have not yet reached global targets for universal coverage of ITNs. To reduce the gaps in ITN use, it is important to understand the factors associated with ITN use. The goal of this analysis was to determine the factors associated with ITN use in Manica District, Mozambique.

Community acceptability to antimalarial mass drug administrations in Magude district, Southern Mozambique: A mixed methods study

March 24, 2021 - 14:03 -- Open Access
Galatas B, Nhantumbo H, Munguambe K, et al.
PLoS One. 2021 Mar 23;16(3):e0249080

This study aimed to capture the acceptability prior to, during and after the implementation of the first year of MDA rounds conducted under the Magude project, a malaria elimination project in southern Mozambique.


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