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South Asia

Genetic surveillance in the Greater Mekong subregion and South Asia to support malaria control and elimination

August 10, 2021 - 18:10 -- Open Access
Jacob CG, Thuy-Nhien N, Miotto O, et al.
Elife. 2021 Aug 10;10:e62997

National Malaria Control Programmes (NMCPs) currently make limited use of parasite genetic data. We have developed GenRe-Mekong, a platform for genetic surveillance of malaria in the Greater Mekong Subregion (GMS) that enables NMCPs to implement large-scale surveillance projects by integrating simple sample collection procedures in routine public health procedures.

Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa

June 1, 2021 - 15:36 -- Open Access
Benavente ED, Manko E, Clark TG, et al.
Nat Commun. 2021 May 26;12(1):3160

Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites.

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