The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10237 malaria professionals are enjoying the free benefits of MalariaWorld today

proteomics

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

December 2, 2019 - 14:43 -- Open Access
Author(s): 
Yang T, Yeoh LM, Cobbold SA, et al.
Reference: 
Cell Rep. 2019 Nov 26;29(9):2917-2928.e5

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise role of K13 remains unclear. Here, we show that K13 mutations result in decreased expression of this protein, while mislocalization of K13 mimics resistance-conferring mutations, pinpointing partial loss of function of K13 as the relevant molecular event.

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

November 7, 2019 - 21:20 -- Open Access
Author(s): 
Lindner SE, Swearingen KE, Shears MJ, Walker MP, Vrana EN, Hart KJ, Minns AM, Sinnis P, Moritz RL, Kappe SHI
Reference: 
Nat Commun. 2019 Oct 31;10(1):4964

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes.

Medical Condition: 
Subscribe to RSS - proteomics