proteomics

Comprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates

Tags:

proteomics, p. vivax, human plasma, parasite, Isolates

Author(s):

Venkatesh A, Aggarwal S, Kumar S, Rajyaguru S, Kumar V, Bankar S, Shastri J, Patankar S, Srivastava S

Reference:

BMC Infect Dis. 2020 Mar 2;20(1):188

In recent times, Plasmodium vivax (P. vivax) has become a serious threat to public health due to its ability to cause severe infection with fatal outcomes. Its unique biology makes it resilient to control measures that are otherwise effective against P. falciparum. A deeper understanding of P. vivax biology and pathogenesis is, therefore, essential for developing the right control strategies.

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

Tags:

malaria artemisinin, antimalarial, kelch13, proteomics, silac, protein turnover, cytostome

Author(s):

Yang T, Yeoh LM, Cobbold SA, et al.

Reference:

Cell Rep. 2019 Nov 26;29(9):2917-2928.e5

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise role of K13 remains unclear. Here, we show that K13 mutations result in decreased expression of this protein, while mislocalization of K13 mimics resistance-conferring mutations, pinpointing partial loss of function of K13 as the relevant molecular event.

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

Tags:

transcriptomics, proteomics, malaria, sporozoite

Author(s):

Lindner SE, Swearingen KE, Shears MJ, Walker MP, Vrana EN, Hart KJ, Minns AM, Sinnis P, Moritz RL, Kappe SHI

Reference:

Nat Commun. 2019 Oct 31;10(1):4964

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes.

Medical Condition:

malaria

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