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Multiplexed quantitative proteomics provides mechanistic cues for malaria severity and complexity

November 19, 2020 - 13:17 -- Open Access
Kumar V, Ray S, Srivastava S, et al.
Commun Biol. 2020 Nov 17;3(1):683

Management of severe malaria remains a critical global challenge. In this study, using a multiplexed quantitative proteomics pipeline we systematically investigated the plasma proteome alterations in non-severe and severe malaria patients.

NOT Open Access | Identification of Lysinibacillus sphaericus Binary toxin binding proteins in a malarial mosquito cell line by proteomics: A novel approach towards improving mosquito control

July 29, 2020 - 10:19 -- NOT Open Access
Riaz MA, Adang MJ, Hua G, Rezende TMT, Rezende AM, Shen GM
J Proteomics. 2020 Jul 23:103918

Bacterial insecticidal proteins, such as the Bin toxin from Lysinibacillus sphaericus, could be used more extensively to control insecticide resistant mosquitoes. This study was aimed at identification of mosquito cell proteins binding Bin toxin. Results showed that purified toxin was toxic to Anopheles gambiae larvae and Ag55 cultured cells. Clathrin heavy chain (an endocytosis protein) and glycolytic enzymes such as pyruvate kinase, enolase and dihydrolipoamide dehydrogenase were identified as binders of Bin toxin.

Comprehensive proteomics investigation of P. vivax-infected human plasma and parasite isolates

March 9, 2020 - 14:20 -- Open Access
Venkatesh A, Aggarwal S, Kumar S, Rajyaguru S, Kumar V, Bankar S, Shastri J, Patankar S, Srivastava S
BMC Infect Dis. 2020 Mar 2;20(1):188

In recent times, Plasmodium vivax (P. vivax) has become a serious threat to public health due to its ability to cause severe infection with fatal outcomes. Its unique biology makes it resilient to control measures that are otherwise effective against P. falciparum. A deeper understanding of P. vivax biology and pathogenesis is, therefore, essential for developing the right control strategies. 

Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance

December 2, 2019 - 14:43 -- Open Access
Yang T, Yeoh LM, Cobbold SA, et al.
Cell Rep. 2019 Nov 26;29(9):2917-2928.e5

Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs) is associated with mutations in Kelch13 (K13), although the precise role of K13 remains unclear. Here, we show that K13 mutations result in decreased expression of this protein, while mislocalization of K13 mimics resistance-conferring mutations, pinpointing partial loss of function of K13 as the relevant molecular event.

Transcriptomics and proteomics reveal two waves of translational repression during the maturation of malaria parasite sporozoites

November 7, 2019 - 21:20 -- Open Access
Lindner SE, Swearingen KE, Shears MJ, Walker MP, Vrana EN, Hart KJ, Minns AM, Sinnis P, Moritz RL, Kappe SHI
Nat Commun. 2019 Oct 31;10(1):4964

Plasmodium sporozoites are transmitted from infected mosquitoes to mammals, and must navigate the host skin and vasculature to infect the liver. This journey requires distinct proteomes.

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