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bone marrow; chloroquine; cynomolgi; hypnozoite; liver; malaria; merozoite; Plasmodium; primaquine; recrudescence; recurrence; relapse; spleen; tafenoquine; vivax

P. vivax Malaria Recurrence and Human Nature

October 13, 2021 - 17:03 -- Miles Markus

People who did not believe the non-reinfection, non-circulating merozoite-related P. vivax malarial recurrence concept [explained here: https://doi.org/10.2147/TCRM.S269336] are now quietly starting to echo it.

However, it is interesting to note that this has directly or indirectly been done by the authors of some papers while studiously avoiding inclusion of any reference to where the idea (prediction) came from in the first place, thereby revealing their true colours.

Plasmodium vivax: Relapses or Recrudescences?

September 24, 2021 - 03:10 -- Miles Markus

For the past 40 years, we have readily ascribed recurrences of Plasmodium vivax malaria to hypnozoite activation.

But during this 40-year period, we have been completely unaware that there are extremely large numbers of merozoites (compared to only a few hypnozoites) hiding outside the peripheral bloodstream – not only sequestered but happily multiplying extravascularly in tissues.

Plasmodium vivax Malarial Recurrence Theory Vindicated

May 29, 2021 - 20:03 -- Miles Markus

The idea that the non-circulating parasite origin of Plasmodium vivax malarial recurrence is both hypnozoites [1,2] and merozoites (not hypnozoites only) dates from 2011 [3,4]. The history appears in Table 1 in [4]. There is recent (and superb) evidence that my decade-old, bimodal recurrence hypothesis must be correct.

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