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bone marrow; control; elimination; eradication; history; hypnozoite; malaria; Plasmodium cynomolgi; Plasmodium vivax; primaquine; recrudescence; recurrence; relapse

Bone Marrow and Hypnozoite-Independent Plasmodium vivax Malarial Recurrences

May 11, 2018 - 20:19 -- Miles Markus

As shown by the record of historical events listed in Table 1 in a recent review of biological concepts in recurrent vivax malaria, the question of a hypnozoite-independent, non-circulating origin(s) of recurrences was first raised approximately 7 years ago. (Link to the paper and Table 1 [click here]). More specifically, parasites in bone marrow as a possible contributing source are discussed in this 2018 article, the matter having initially been debated in a 2017 publication cited therein.

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