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CD4+ T cells

Moringa oleifera treatment increases Tbet expression in CD4+ T cells and remediates immune defects of malnutrition in Plasmodium chabaudi-infected mice

February 10, 2020 - 16:24 -- Open Access
Author(s): 
Jennifer Pilotos, Kadra Abdu Ibrahim, Chishimba Nathan Mowa and Michael Makokha Opata
Reference: 
Malaria Journal 2020 19:62, 7 February 2020

Malaria is a worldwide problem that affects millions of people yearly. In rural areas where anti-malarial drugs are not easily accessible, many people use herbal treatments, such as Moringa oleifera, to treat a variety of diseases and ailments including malaria. While Moringa is reported to possess potent and curative anti-malarial properties, previous studies have mostly been restricted to assessment of parasitaemia. In this study, the effect of Moringa on malaria immunity in a murine model was investigated.

Not Open Access | The regulation of CD4+ T cells during malaria

January 20, 2020 - 14:58 -- NOT Open Access
Author(s): 
Kumar R, Loughland JR, Ng SS, Boyle MJ, Engwerda CR
Reference: 
Immunological Reviews, Volume293, Issue1, January 2020 Pages 70-87

Malaria is a major global health problem. Despite decades of research, there is still no effective vaccine to prevent disease in the majority of people living in malaria‐endemic regions. Additionally, drug treatment options are continually threatened by the emergence of drug‐resistant parasites. Immune responses generated against Plasmodium parasites that cause malaria are generally not sufficient to prevent the establishment of infection and can even contribute to the development of disease, unless individuals have survived multiple infections.

Not Open Access | The regulation of CD4+ T cells during malaria

November 7, 2019 - 21:31 -- NOT Open Access
Author(s): 
Kumar R, Loughland JR, Ng SS, Boyle MJ, Engwerda CR
Reference: 
Immunol Rev. 2019 Nov 1

Malaria is a major global health problem. Despite decades of research, there is still no effective vaccine to prevent disease in the majority of people living in malaria-endemic regions.

Medical Condition: 
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