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new transmission drugs

Plasmodium falciparum LipB mutants display altered redox and carbon metabolism in asexual stages and cannot complete sporogony in Anopheles mosquitoes

May 5, 2021 - 11:38 -- Open Access
Biddau M, Santha Kumar TR, Sheiner L, et al.
Int J Parasitol. 2021 May;51(6):441-453

Malaria is still one of the most important global infectious diseases. Emergence of drug resistance and a shortage of new efficient antimalarials continue to hamper a malaria eradication agenda. Malaria parasites are highly sensitive to changes in the redox environment. Understanding the mechanisms regulating parasite redox could contribute to the design of new drugs.

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