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travellers

Malaria in travellers in the time of corona

September 30, 2020 - 11:54 -- Open Access
Author(s): 
Lev D, Biber A, Lachish T, Leshem E, Schwartz E
Reference: 
J Travel Med. 2020 Sep 26;27(6):taaa067

Fever is a common symptom among returned ill-travellers and has many possible etiologies. Of potential causes, malaria is by far the most frequent diagnosis leading to hospitalization and death among travellers.

NOT Open Access | Prevalence of Plasmodium falciparum Kelch 13 (PfK13) and ubiquitin-specific protease 1 (pfubp1) gene polymorphisms in returning travellers from Africa reported in Eastern China

August 26, 2020 - 14:53 -- NOT Open Access
Author(s): 
Yan H, Kong X, Zhang T, Xiao H, Feng X, Tu H, Feng J
Reference: 
Antimicrob Agents Chemother. 2020 Aug 24:AAC.00981-20

Delayed clearance of Plasmodium falciparum by artemisinin-based combination therapies (ACTs) has already been observed in African isolates. Here, we aimed to investigate the prevalence of polymorphisms in two genes correlated with delayed parasite clearance, P. falciparum Kelch 13 (PfK13) and ubiquitin-specific protease 1 (pfubp1), among returning travellers from African countries reported in eastern China and to provide baseline data for antimalarial drug resistance (ART) surveillance and evaluation.

Detection of remaining Plasmodium DNA and gametocytes during follow up after curative malaria treatment among returned travellers in Norway

August 19, 2020 - 16:07 -- Open Access
Author(s): 
Christel Gill Haanshuus and Kristine Mørch
Reference: 
Malaria Journal 2020 19:296, 19 August 2020

PCR can be positive weeks after effective malaria treatment, potentially leading to over diagnose of recrudescence and re-infections. The DNA detected by PCR post-treatment might stem from residuals of destroyed asexual parasites, or from live gametocytes. The objective of this clinical observational study was to describe the presence of positive PCR for Plasmodium falciparum and Plasmodium vivax in follow-up samples post-treatment from returned travellers, and the proportion of positive PCR due to gametocytes.

Molecular detection of antimalarial drug resistance in Plasmodium vivax from returned travellers to NSW, Australia during 2008-2018

February 16, 2020 - 09:23 -- Open Access
Author(s): 
Noisang C, Meyer W, Sawangjaroen N, Ellis J, Lee R
Reference: 
Pathogens. 2020 Feb 5;9(2). pii: E101

To monitor drug resistance in Plasmodium vivax, a multidrug resistance 1 (Pvmdr1) gene and a putative transporter protein (Pvcrt-o) gene were used as molecular markers for chloroquine resistance. The biomarkers, the dihydrofolate reductase (Pvdhfr) gene and the dihydropteroate synthetase (Pvdhps) gene, were also used for the detection of resistance to sulphadoxine-pyrimethamine (SP); this drug is often accidentally used to treat P. vivax infections. Clinical blood samples (n = 120) were collected from patients who had been to one of eight malaria-endemic countries and diagnosed with P. vivax infection.

A systematic review of factors affecting adherence to malaria chemoprophylaxis amongst travellers from non-endemic countries

January 15, 2020 - 14:37 -- Open Access
Author(s): 
Julian Ahluwalia, Samantha K. Brooks, John Weinman and G. James Rubin
Reference: 
Malaria Journal 2020 19:16, 13 January 202

The aim of this systematic review was to identify predictors of actual or intended adherence with malaria chemoprophylaxis amongst travellers from non-endemic countries visiting endemic countries.

Not Open Access | Imported malaria and artemisinin-based combination therapy failure in travellers returning to Belgium: A retrospective study

November 7, 2019 - 21:48 -- NOT Open Access
Author(s): 
Rovira-Vallbona E, Bottieau E, Guetens P, Verschueren J, Rebolledo J, Nulens E, Van der Hilst J, Clerinx J, Van Esbroeck M, Rosanas-Urgell A
Reference: 
Travel Med Infect Dis. 2019 Oct 30:101505 [Epub ahead of print]

BACKGROUND

Malaria (Plasmodium spp) remains a top cause of travel-associated morbidity among European residents. Here, we describe recent trends of imported malaria to Belgium and characterize the first cases of P.falciparum failure to artemisinin combination therapy (ACT).

METHODS

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