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NOT Open Access | CD49d marks Th1 and Tfh-like antigen-specific CD4 + T cells during Plasmodium chabaudi infection

May 5, 2021 - 08:40 -- NOT Open Access
Jian JY, Inoue SI, Yui K, et al.
Int Immunol. 2021 Apr 29:dxab020

Upon activation, specific CD4 + T cells upregulate the expression of CD11a and CD49d, surrogate markers of pathogen-specific CD4 + T cells. However, using TCR transgenic mice specific for a Plasmodium antigen, termed PbT-II, we found that activated CD4 + T cells develop not only to CD11a hiCD49d hi cells, but also to CD11a hiCD49d lo cells during acute Plasmodium infection. CD49d hi PbT-II cells, localized in the red pulp of spleens, expressed transcription factor T-bet, and produced IFN-γ, indicating that they were Th1-type cells.

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