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B cells

Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response

October 15, 2020 - 08:50 -- Open Access
Author(s): 
McNamara HA, Idris AH, Cockburn IA, et al.
Reference: 
Cell Host Microbe. 2020 Oct 7;28(4):572-585.e7

Generating sufficient antibody to block infection is a key challenge for vaccines against malaria. Here, we show that antibody titers to a key target, the repeat region of the Plasmodium falciparum circumsporozoite protein (PfCSP), plateaued after two immunizations in a clinical trial of the radiation-attenuated sporozoite vaccine. To understand the mechanisms limiting vaccine responsiveness, we developed immunoglobulin (Ig)-knockin mice with elevated numbers of PfCSP-binding B cells.

NOT Open Access | B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

February 17, 2020 - 12:05 -- NOT Open Access
Author(s): 
Arroyo EN, Pepper M
Reference: 
J Exp Med. 2020 Feb 3;217(2). pii: e20190849

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression.

Not Open Access | B cells are sufficient to prime the dominant CD4+ Tfh response to Plasmodium infection

November 30, 2019 - 20:01 -- NOT Open Access
Author(s): 
Arroyo EN, Pepper M.
Reference: 
J Exp Med. 2019 Nov 20. pii: jem.20190849.

CD4+ T follicular helper (Tfh) cells dominate the acute response to a blood-stage Plasmodium infection and provide signals to direct B cell differentiation and protective antibody expression. We studied antigen-specific CD4+ Tfh cells responding to Plasmodium infection in order to understand the generation and maintenance of the Tfh response.

Corrigendum: Chronic Exposure to Malaria Is Associated with Inhibitory and Activation Markers on Atypical Memory B Cells and Marginal Zone-Like B Cells

November 7, 2019 - 22:03 -- Open Access
Author(s): 
Ubillos I, Campo JJ, Requena P, Ome-Kaius M, Hanieh S, Rose H, Samol P, Barrios D, Jiménez A, Bardají A, Mueller I, Menéndez C, Rogerson S, Moncunill G, Dobaño C.
Reference: 
Front Immunol. 2019 Oct 17;10:2427 (eCollection 2019)

In the original article, we neglected to include the co-funder “FEDER funds/European Regional Development Fund (ERDF)” to “Instituto de Salud Carlos III (grant number PI14/01422)”.

Medical Condition: 
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