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Repeated sampling improved the sensitivity of malaria microscopy in children under six years

November 7, 2020 - 12:46 -- Open Access
Aninagyei E
BMC Res Notes. 2020 Nov 4;13(1):508

Microscopy remains the gold standard for identification of malaria parasites. However, the sensitivity of malaria microscopy is low. This study evaluated the impact of repeated sampling up to 12 h in 177 children < 6 years with suspected malaria.

Clustering-Based Dual Deep Learning Architecture for Detecting Red Blood Cells in Malaria Diagnostic Smears

November 3, 2020 - 15:25 -- Open Access
Kassim YM, Palaniappan K, Yang F, Poostchi M, Palaniappan N, Maude RJ, Antani S, Jaeger S
IEEE J Biomed Health Inform. 2020 Oct 29;PP

Computer-assisted algorithms have become a mainstay of biomedical applications to improve accuracy and reproducibility of repetitive tasks like manual segmentation and annotation. We propose a novel pipeline for red blood cell detection and counting in thin blood smear microscopy images, named RBCNet, using a dual deep learning architecture. RBCNet consists of a U-Net first stage for cell-cluster segmentation, followed by a second stage Faster R-CNN for detecting small cell objects within clusters, identified as connected components from the U-Net stage.

Evaluation of malaria microscopy diagnostic performance at private health facilities in Tanzania

December 2, 2019 - 14:55 -- Open Access
Ngasala B, Bushukatale S.
Malaria Journal volume 18, 375 (2019)

The World Health Organization (WHO) recommends use of parasitological diagnosis of malaria for all age groups in all malaria transmission settings. Many private health facilities rely on malaria microscopy for malaria diagnosis. However, quality of malaria microscopy is affected by number of factors including availability of skilled laboratory microscopists and lack of quality assurance systems in many malaria endemic countries. This study was carried out to assess quality of malaria microscopy in selected private health facilities in Tanzania.


Diagnostic performance of CareStart™ malaria HRP2/pLDH test in comparison with standard microscopy for detection of uncomplicated malaria infection among symptomatic patients, Eastern Coast of Tanzania

November 11, 2019 - 16:02 -- Open Access
George M. Bwire, Billy Ngasala, Manase Kilonzi, Wigilya P. Mikomangwa, Fatuma F. Felician and Appolinary A. R. Kamuhabwa
Malaria Journal 2019 18:354, 5 November 2019

CareStart™ malaria HRP2/pLDH (Pf/pan) combo test is one of the several rapid diagnostic tests (RDT) approved for diagnosis of malaria at the point of care in Tanzania. However, there are limited studies on the diagnostic performance of RDT after wide scale use in primary health care facilities in Tanzania. 

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