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PfVps32

The ESCRT-III machinery participates in the production of extracellular vesicles and protein export during Plasmodium falciparum infection

April 6, 2021 - 14:08 -- Open Access
Author(s): 
Avalos-Padilla Y, Georgiev VN, Lantero E, Pujals S, Verhoef R, N Borgheti-Cardoso L, Albertazzi L, Dimova R, Fernàndez-Busquets X
Reference: 
PLoS Pathog. 2021 Apr 2;17(4):e1009455

Infection with Plasmodium falciparum enhances extracellular vesicle (EV) production in parasitized red blood cells (pRBCs), an important mechanism for parasite-to-parasite communication during the asexual intraerythrocytic life cycle. The endosomal sorting complex required for transport (ESCRT), and in particular the ESCRT-III sub-complex, participates in the formation of EVs in higher eukaryotes.

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