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iRBCs

Adipose tissue parasite sequestration drives leptin production in mice and correlates with human cerebral malaria

March 26, 2021 - 16:05 -- Open Access
Author(s): 
Mejia P, Treviño-Villarreal JH, Mitchell JR, et al.
Reference: 
Sci Adv. 2021 Mar 24;7(13):eabe2484

Circulating levels of the adipokine leptin are linked to neuropathology in experimental cerebral malaria (ECM), but its source and regulation mechanism remain unknown. Here, we show that sequestration of infected red blood cells (iRBCs) in white adipose tissue (WAT) microvasculature increased local vascular permeability and leptin production. Mice infected with parasite strains that fail to sequester in WAT displayed reduced leptin production and protection from ECM.

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