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sphingosine 1-phosphate

NOT Open Access | Malaria link of hypertension: a hidden syndicate of angiotensin II, bradykinin and sphingosine 1-phosphate

March 10, 2021 - 13:34 -- NOT Open Access
Author(s): 
Dhangadamajhi G, Singh S
Reference: 
Hum Cell. 2021 Mar 8


In malaria-endemic countries, the burden of hypertension is on the rise. Although malaria and hypertension seem to have no direct link, several studies in recent years support their possible link. Three bioactive molecules such as angiotensin II (Ang II), bradykinin (BK) and sphingosine 1-phosphate (S1P) are crucial in regulating blood pressure. While the increased level of Ang II and S1P are responsible for inducing hypertension, BK is arthero-protective and anti-hypertensive.

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