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angiotensin II

NOT Open Access | Evolutionary trilogy of malaria, angiotensin II and hypertension: deeper insights and the way forward

September 8, 2021 - 15:59 -- NOT Open Access
Author(s): 
De A, Tiwari A, Pande V, Sinha A
Reference: 
J Hum Hypertens. 2021 Sep 3


Despite clinical and pathological distinctions between malaria and hypertension, accumulated epidemiological and evolutionary evidence indicate the need of deeper understanding how severe malaria contributes to elevated hypertension risk. Malaria is said to exert strong selection pressure on the host genome, thus selecting certain genetic polymorphisms.

NOT Open Access | Malaria link of hypertension: a hidden syndicate of angiotensin II, bradykinin and sphingosine 1-phosphate

March 10, 2021 - 13:34 -- NOT Open Access
Author(s): 
Dhangadamajhi G, Singh S
Reference: 
Hum Cell. 2021 Mar 8


In malaria-endemic countries, the burden of hypertension is on the rise. Although malaria and hypertension seem to have no direct link, several studies in recent years support their possible link. Three bioactive molecules such as angiotensin II (Ang II), bradykinin (BK) and sphingosine 1-phosphate (S1P) are crucial in regulating blood pressure. While the increased level of Ang II and S1P are responsible for inducing hypertension, BK is arthero-protective and anti-hypertensive.

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