The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 11105 malaria professionals are enjoying the free benefits of MalariaWorld today

environmental elasticity

Malaria parasites differentially sense environmental elasticity during transmission

March 10, 2021 - 13:24 -- Open Access
Author(s): 
Ripp J, Kehrer J, Smyrnakou X, Tisch N, Tavares J, Amino R, Ruiz de Almodovar C, Frischknecht F
Reference: 
EMBO Mol Med. 2021 Mar 5:e13933

Transmission of malaria-causing parasites to and by the mosquito relies on active parasite migration and constitutes bottlenecks in the Plasmodium life cycle. Parasite adaption to the biochemically and physically different environments must hence be a key evolutionary driver for transmission efficiency. To probe how subtle but physiologically relevant changes in environmental elasticity impact parasite migration, we introduce 2D and 3D polyacrylamide gels to study ookinetes, the parasite forms emigrating from the mosquito blood meal and sporozoites, the forms transmitted to the vertebrate host.

Subscribe to RSS - environmental elasticity