The world's scientific and social network for malaria professionals
Subscribe to free Newsletter | 10858 malaria professionals are enjoying the free benefits of MalariaWorld today

antitumor

Plasmodium infection inhibits triple negative 4T1 breast cancer potentially through induction of CD8(+) T cell-mediated antitumor responses in mice

March 9, 2021 - 15:50 -- Open Access
Author(s): 
Pan J, Ma M, Qin L, Kang Z, Adah D, Tao Z, Li X, Dai L, Zhao S, Chen X, Zhou Q
Reference: 
Biomed Pharmacother. 2021 Mar 3;138:111406

We previously reported that Plasmodium infection promotes antitumor immunity in a murine Lewis lung cancer. In this study, we investigated the effects of Plasmodium infection on the tumor inhibition and antitumor CD8+ T cell responses in a murine triple negative breast cancer (TNBCA) model. The results showed that Plasmodium infection significantly inhibited tumor growth, and increased the survival rate of the tumor-bearing mice. Both effector and memory CD8+ T cells were increased in peripheral blood and tumor-draining lymph node (DLN) in the infected mice.

Subscribe to RSS - antitumor