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3-hydroxy-propanamidine

NOT Open Access | 3-Hydroxy-propanamidines, a New Class of Orally Active Antimalarials Targeting Plasmodium falciparum

March 9, 2021 - 15:29 -- NOT Open Access
Author(s): 
Knaab TC, Held J, Kurz T, et al.
Reference: 
J Med Chem. 2021 Mar 5

3-Hydroxypropanamidines are a new promising class of highly active antiplasmodial agents. The most active compound 22 exhibited excellent antiplasmodial in vitro activity with nanomolar inhibition of chloroquine-sensitive and multidrug-resistant parasite strains of Plasmodium falciparum (with IC50 values of 5 and 12 nM against 3D7 and Dd2 strains, respectively) as well as low cytotoxicity in human cells.

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