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cerebrovascular dysfunction

NOT Open Access | Perillyl alcohol reduces parasite sequestration and cerebrovascular dysfunction during experimental cerebral malaria

March 4, 2021 - 11:23 -- NOT Open Access
Marin AA, Murillo O, Sussmann RA, Ortolan LS, Battagello DS, de Castro Quirino T, Bittencourt JC, Epiphanio S, Katzin AM, Carvalho LJM
Antimicrob Agents Chemother. 2021 Mar 1:AAC.00004-21

Cerebral malaria (CM) is a severe immunovasculopathy which presents high mortality rate (15-20%), despite the availability of artemisinin-based therapy. More effective immunomodulatory and/or antiparasitic therapies are urgently needed. Experimental Cerebral Malaria (ECM) in mice is used to elucidate aspects involved in this pathology since manifests many of the neurological features of CM.

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