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Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

March 4, 2021 - 11:18 -- Open Access
Milne K, Ivens A, Spence PJ, et al.
Elife. 2021 Mar 2;10:e62800

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variation observed in controlled human malaria infection (CHMI).

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