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HLA-C

Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity

March 3, 2021 - 15:24 -- Open Access
Author(s): 
Stephen Tukwasibwe, James A. Traherne, Annettee Nakimuli, et al.
Reference: 
Malaria Journal 2021 20:111, 25 February 2021

Malaria is one of the most serious infectious diseases in the world. The malaria burden is greatly affected by human immunity, and immune responses vary between populations. Genetic diversity in KIR and HLA-C genes, which are important in immunity to infectious diseases, is likely to play a role in this heterogeneity. Several studies have shown that KIR and HLA-C genes influence the immune response to viral infections, but few studies have examined the role of KIR and HLA-C in malaria infection, and these have used low-resolution genotyping. The aim of this study was to determine whether genetic variation in KIR and their HLA-C ligands differ in Ugandan populations with historically varied malaria transmission intensity using more comprehensive genotyping approaches.

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