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quinoline carboxamide

NOT Open Access | Quinoline carboxamide core moiety-based compounds inhibit P. falciparumfalcipain-2: Design, synthesis and antimalarial efficacy studies

March 2, 2021 - 15:34 -- NOT Open Access
Singh A, Kalamuddin M, Maqbool M, Mohmmed A, Malhotra P, Hoda N
Bioorg Chem. 2021 Mar;108:104514

Targeting Falcipain-2 (FP2) for the development of antimalarials is a promising and established concept in antimalarial drug discovery and development. FP2, a member of papain-family cysteine protease of the malaria parasite Plasmodium falciparum holds an important role in hemoglobin degradation pathway. A new series of quinoline carboxamide-based compounds was designed, synthesized and evaluated for antimalarial activity.

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