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choline derivative

NOT Open Access | Choline and PEG dually modified artemether nano delivery system targeting intra-erythrocytic Plasmodium and its pharmacodynamics in vivo

March 2, 2021 - 15:17 -- NOT Open Access
Wang R, Shi G, Chai L, Wang R, Zhang G, Ren G, Zhang S
Drug Dev Ind Pharm. 2021 Mar 1:1-11

The choline derivative (CD) and polyethylene-glycol (PEG) dually modified artemether (ARM) nanostructured lipid carriers (CD-PEG-ARM-NLC) have been designed to prolong the circulation of ARM in blood, as well as to develop targeting for new permeability pathways (NPPs) and erythrocyte choline carriers (ECCs) that are expressed on the Plasmodium-infected erythrocyte membrane.

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