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7-dimethoxyquinazoline-2 4-diamines

Quest for a potent antimalarial drug lead: Synthesis and evaluation of 6,7-dimethoxyquinazoline-2,4-diamines

March 2, 2021 - 11:25 -- Open Access
Mizukawa Y, Ikegami-Kawai M, Itoh I, et al.
Bioorg Med Chem. 2021 Mar 1;33:116018

Quinazolines have long been known to exert varied pharmacologic activities that make them suitable for use in treating hypertension, viral infections, tumors, and malaria. Since 2014, we have synthesized approximately 150 different 6,7-dimethoxyquinazoline-2,4-diamines and evaluated their antimalarial activity via structure-activity relationship studies.

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