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asymptomatic person

High frequency of the Duffy-negative genotype and absence of Plasmodium vivax infections in Ghana

February 20, 2021 - 08:35 -- Open Access
Author(s): 
Charles A. Brown, Prince J. Pappoe-Ashong, Nancy Duah, Anita Ghansah, Harry Asmah, Edwin Afari and Kwadwo A. Koram
Reference: 
Malaria Journal 2021 20:99, 17 February 2021

Recent studies from different malaria-endemic regions including western Africa have now shown that Plasmodium vivax can infect red blood cells (RBCs) and cause clinical disease in Duffy-negative people, though the Duffy-negative phenotype was thought to confer complete refractoriness against blood invasion with P. vivax. The actual prevalence of P. vivax in local populations in Ghana is unknown and little information is available about the distribution of Duffy genotypes. The aim of this study was to assess the prevalence of P. vivax in both asymptomatic and symptomatic outpatients and the distribution of Duffy genotypes in Ghana.

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