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salivary gland sporozoite

Estimating the extrinsic incubation period of malaria using a mechanistic model of sporogony

February 17, 2021 - 09:27 -- Open Access
Author(s): 
Stopard IJ, Churcher TS, Lambert B
Reference: 
PLoS Comput Biol. 2021 Feb 16;17(2):e1008658

During sporogony, malaria-causing parasites infect a mosquito, reproduce and migrate to the mosquito salivary glands where they can be transmitted the next time blood feeding occurs. The time required for sporogony, known as the extrinsic incubation period (EIP), is an important determinant of malaria transmission intensity. The EIP is typically estimated as the time for a given percentile, x, of infected mosquitoes to develop salivary gland sporozoites (the infectious parasite life stage), which is denoted by EIPx. Many mechanisms, however, affect the observed sporozoite prevalence including the human-to-mosquito transmission probability and possibly differences in mosquito mortality according to infection status.

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