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Circumsporozoite Surface Protein-based malaria vaccines: a review

February 6, 2021 - 10:47 -- Open Access
Almeida MEM, Vasconcelos MGS, Tarragô AM, Mariúba LAM
Rev Inst Med Trop Sao Paulo. 2021 Jan 29;63:e11

Malaria represents a serious public health problem, presenting with high rates of incidence, morbidity and mortality in tropical and subtropical regions of the world. According to the World Health Organization, in 2018 there were 228 million cases and 405 thousand deaths caused by this disease in the world, affecting mainly children and pregnant women in Africa. Despite the programs carried out to control this disease, drug resistance and invertebrate vector resistance to insecticides have generated difficulties. An efficient vaccine against malaria would be a strategy with a high impact on the eradication and control of this disease.

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