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Population genetic and biophysical evidences reveal that purifying selection shapes the genetic landscape of Plasmodium falciparum RH ligands in Chhattisgarh and West Bengal, India

October 15, 2020 - 08:19 -- Open Access
Sharmistha Ghoshal, Pramita Chowdhury, Sanhita Ray, Mitashree Mitra, Sumana Datta Kanjilal, Srikanta Sen, Anjan Kr. Dasgupta and Sanghamitra Sengupta
Malaria Journal 2020 19:367,14 October 2020

Reticulocyte binding protein-like homologs (RHs) are currently being evaluated as anti-erythrocytic stage vaccine targets against Plasmodium falciparum malaria. Present study explores the possible evolutionary drivers shaping the genetic organization of Pfrhs in Indian parasite population. It simultaneously evaluates a putative gain-of-function variant of PfRH5, a keystone member of PfRH family.

Single-nucleotide polymorphism characterization of gametocyte development 1 gene in Plasmodium falciparum isolates from Baringo, Uasin Gishu, and Nandi Counties, Kenya

March 17, 2020 - 15:12 -- Open Access
Bungei JK, Mobegi VA, Nyanjom SG
Heliyon. 2020 Mar 3; 6(3):e03453

Plasmodium falciparum relies on gametocytogenesis to transmit from humans to mosquitoes. Gametocyte development 1 (Pfgdv1) is an upstream activator and epigenetic controller of gametocytogenesis. The emergence of drug resistance is a major public health concern and this requires the development of new strategies that target the transmission of malaria. As a putative drug target, Pfgdv1 has not been characterized to identify its polymorphisms and alleles under selection and how such polymorphisms influence protein structure.

NOT Open Access | MiRNA-146a Polymorphism Was Not Associated with Malaria in Southern India

March 9, 2020 - 14:35 -- NOT Open Access
van Loon W, Gai PP, Kulkarni SS, Rasalkar R, Siegert K, Wedam J, Boloor A, Baliga S, Kumar A, Jain A, Mahabala C, Shenoy D, Devi R, Gai P, Mockenhaupt FP
Am J Trop Med Hyg. 2020 Mar 2

Micro-RNAs (miRNAs) play a crucial role in immune regulation, and a common miRNA-146a polymorphism (rs2910164) increased the odds of falciparum malaria in pregnant African women. Here, we examined whether this association holds true in a different population, that is, 449 mainly male and adult malaria patients and 666 community controls in southwestern India. Plasmodium vivax malaria (67%) predominated over falciparum malaria (11%) and mixed species infections (22%).

Analysis of Plasmodium falciparum Rh2b deletion polymorphism across different transmission areas

February 11, 2020 - 15:51 -- Open Access
Yaw Aniweh, Jonathan Suurbaar, Gordon A. Awandare, et al.
Sci Rep. 2020; 10:1498.

Despite significant progress in controlling malaria, the disease remains a global health burden. The intricate interactions the parasite Plasmodium falciparum has with its host allows it to grow and multiply in human erythrocytes. The mechanism by which P. falciparum merozoites invade human erythrocytes is complex, involving merozoite proteins as well as erythrocyte surface proteins. Members of the P. falciparum reticulocyte binding-like protein homolog (PfRh) family of proteins play a pivotal role in merozoite invasion and hence are important targets of immune responses.

NOT Open Access | MHC Class II (DRB) Promoter Polymorphism and Its Role in Parasite Control among Malaria Patients

January 27, 2020 - 13:21 -- NOT Open Access
Sar P, Agarwal A, Vadodariya DH, Kariya H, Khuman J, Dalai S
J Immunol January 15, 2020, ji1900558

MHC class II (MHCII) molecules are cell surface glycoproteins that play an important role to develop adaptive immune responses. MHCII-disease association is not restricted to structural variation alone but also may extend to genetic variations, which may modulate gene expression. The observed variations in class II gene expression make it possible that the association of MHCII polymorphism with diseases may relate to the level of gene expression in addition to the restriction of response to Ag.

NOT Open Access | Polymorphism and natural selection in the merozoite surface protein 3F2 (PVX_97710) locus of Plasmodium vivax among field isolates

November 12, 2019 - 15:56 -- NOT Open Access
Napaporn Kuamsab, Chaturong Putaporntip, Somchai Jongwutiwes
Infection, Genetics and Evolution, November 2019, 104058

Plasmodium vivax, the chronic relapsing human malaria parasite with the most widespread distribution, possesses proteins associated with the merozoite surface that could be targets for host immune responses and potential vaccine candidates. Of these, the merozoite surface protein 3 of P. vivax (PvMSP3) is an attractive vaccine target as well as a genetic marker for epidemiological surveillance.

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