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NOT Open Access | Metalloaminopeptidases of the Protozoan Parasite Plasmodium falciparum as Targets for the Discovery of Novel Antimalarial Drugs

February 6, 2021 - 10:50 -- NOT Open Access
Author(s): 
Mills B, Isaac RE, Foster R
Reference: 
J Med Chem. 2021 Feb 3

Malaria poses a significant threat to approximately half of the world's population with an annual death toll close to half a million. The emergence of resistance to front-line antimalarials in the most lethal human parasite species, Plasmodium falciparum (Pf), threatens progress made in malaria control. The prospect of losing the efficacy of antimalarial drugs is driving the search for small molecules with new modes of action.

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