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East Africa

A Severe Case of Falciparum Malaria, 10 Years After Malaria Eradication: A Case Report

July 7, 2021 - 15:05 -- Open Access
Abdullah SJ, Abdulateef DS, Rahman HS, Mahmood SO, Mustafa VN, Ahmed RO, Ahmed RA
Yale J Biol Med. 2021 Jun 30;94(2):277-284

Malaria is a major mosquito-borne public health problem especially in tropical countries. The authors report a malaria infection in a 31-year-old man who had returned from East Africa with developed fever and rigor. Because of his thrombocytopenia, decreased hemoglobin, elevated liver enzymes, and splenomegaly, and because of failure to question about recent travel history, he was initially referred to the hematological hospital and medical staff suspected a hematological problem, so he was investigated for bone marrow aspirate and biopsy.

Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa

June 1, 2021 - 15:36 -- Open Access
Benavente ED, Manko E, Clark TG, et al.
Nat Commun. 2021 May 26;12(1):3160

Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites.

Molecular diagnosis and therapy for Plasmodium ovale infection of a returned traveler from East Africa

May 12, 2021 - 13:09 -- Open Access
Tseng YC, Chang YC, Lee C, Hsu SF, Chang PC, Hsu JJ, Lin PB, Lu MC, Tien N, Hsiao CT
J Formos Med Assoc. 2021 May 6:S0929-6646(21)00170-4

Malaria is an infectious disease caused by Plasmodium parasites that are mainly transmitted through the bites of infected female Anopheles mosquitoes. The average annual number of malaria cases was less than ten in Taiwan in the last five years.

Ten years of monitoring malaria trend and factors associated with malaria test positivity rates in Lower Moshi

April 21, 2021 - 15:02 -- Open Access
Nancy A. Kassam, Robert D. Kaaya, Damian J. Damian, Christentze Schmiegelow, Reginald A. Kavishe, Michael Alifrangis and Christian W. Wang
Malaria Journal 2021 20:193, 20 April 2021

High altitude settings in Eastern Africa have been reported to experience increased malaria burden due to vector habitat expansion. This study explored possible associations between malaria test positivity rates and its predictors including malaria control measures and meteorological factors at a high-altitude, low malaria transmission setting, south of Mount Kilimanjaro.

NOT Open Access | Plasmodium vivax from Duffy-Negative and Duffy-Positive Individuals Shares Similar Gene Pool in East Africa

February 6, 2021 - 10:43 -- NOT Open Access
Kepple D, Hubbard A, Ali MM, Abargero BR, Lopez K, Pestana K, Janies DA, Yan G, Hamid MM, Yewhalaw D, Lo E
J Infect Dis. 2021 Feb 3:jiab063

Plasmodium vivax malaria was thought to be rare in Africa, but an increasing number of P. vivax cases reported across Africa and in Duffy-negative individuals challenges this conventional dogma. The genetic characteristics of P. vivax in Duffy-negative infections, the transmission of P. vivax in East Africa, and the impact of environments on transmission remain largely unknown.

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