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protein acetyl-CoA transporter

NOT Open Access | In-silico profiling and structural insights into the impact of nSNPs in the P. falciparum acetyl-CoA transporter gene to understand the mechanism of drug resistance in malaria

February 3, 2021 - 14:34 -- NOT Open Access
Author(s): 
Sardar R, Katyal N, Ahamad S, Jade DD, Ali S, Gupta D
Reference: 
J Biomol Struct Dyn. 2021 Feb;39(2):558-569

The continuous emergence of resistance to the available drugs poses major constraints in the development of effective therapeutics against malaria. Malaria drug resistance has been attributed to be the manifestation of numerous factors. For example, mutations in the parasite transporter protein acetyl-CoA transporter (Pfact) can remarkably affect its uptake affinity for a drug molecule against malaria, and hence enhance its susceptibility to resistance. To identify major contributors to its loss of functionality, we have thoroughly scrutinized eight such recently reported resistant mutants, via in-silico tools in terms of alterations in different properties.

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