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Dexamethasone increased the survival rate in Plasmodium berghei-infected mice

February 2, 2021 - 16:49 -- Open Access
Moreira DR, Uberti ACMG, Gomes ARQ, Ferreira MES, da Silva Barbosa A, Varela ELP, Dolabela MF, Percário S
Sci Rep. 2021 Jan 29;11(1):2623

The present study aimed to evaluate the effects of dexamethasone on the redox status, parasitemia evolution, and survival rate of Plasmodium berghei-infected mice. Two-hundred and twenty-five mice were infected with Plasmodium berghei and subjected to stimulation or inhibition of NO synthesis. The stimulation of NO synthesis was performed through the administration of L-arginine, while its inhibition was made by the administration of dexamethasone.

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