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pre-clinical murine

Parasite-host dynamics throughout antimalarial drug development stages complicate the translation of parasite clearance

February 2, 2021 - 16:29 -- Open Access
Author(s): 
Burgert L, Zaloumis S, Dini S, Marquart L, Cao P, Cherkaoui M, Gobeau N, McCarthy J, Simpson JA, Möhrle JJ, Penny MA
Reference: 
Antimicrob Agents Chemother. 2021 Feb 1:AAC.01539-20

Ensuring continued success against malaria depends on a pipeline of new antimalarials. Antimalarial drug development utilizes pre-clinical murine and experimental human malaria infection studies to evaluate drug efficacy. A sequential approach is typically adapted, with results from each stage, informing the design of the next stage of development. The validity of this approach depends on confidence that results from murine malarial studies predict the outcome of clinical trials in humans. Parasite clearance rates following treatment are key parameters of drug efficacy.

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