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seasonal

Seasonal malaria vaccination: protocol of a phase 3 trial of seasonal vaccination with the RTS,S/AS01(E) vaccine, seasonal malaria chemoprevention and the combination of vaccination and chemoprevention

September 16, 2020 - 13:13 -- Open Access
Author(s): 
Chandramohan D, Dicko A, Greenwood B, et al.
Reference: 
BMJ Open. 2020 Sep 15;10(9):e035433

Seasonal malaria chemoprevention (SMC), with sulphadoxine-pyrimethamine plus amodiaquine (SP+AQ) is effective but does not provide complete protection against clinical malaria. The RTS,S/AS01E malaria vaccine provides a high level of protection shortly after vaccination, but this wanes rapidly. Such a vaccine could be an alternative or additive to SMC. This trial aims to determine whether seasonal vaccination with RTS,S/AS01E vaccine could be an alternative to SMC and whether a combination of the two interventions would provide added benefits.

Clinical diagnostic evaluation of HRP2 and pLDH-based rapid diagnostic tests for malaria in an area receiving seasonal malaria chemoprevention in Niger

December 30, 2019 - 15:06 -- Open Access
Author(s): 
Matthew E. Coldiron, Bachir Assao, Rebecca F. Grais, et al.
Reference: 
Malaria Journal 2019 18:443, 26 December 2019

Rapid diagnostic tests (RDT) for malaria are common, but their performance varies. Tests using histidine-rich protein 2 (HRP2) antigen are most common, and many have high sensitivity. HRP2 tests can remain positive for weeks after treatment, limiting their specificity and usefulness in high-transmission settings. Tests using Plasmodium lactate dehydrogenase (pLDH) have been less widely used but have higher specificity, mostly due to a much shorter time to become negative.

Modelled and observed mean and seasonal relationships between climate, population density and malaria indicators in Cameroon

November 11, 2019 - 16:24 -- Open Access
Author(s): 
Amelie D. Mbouna, Adrian M. Tompkins, Andre Lenouo, Ernest O. Asare, Edmund I. Yamba and Clement Tchawoua
Reference: 
Malaria Journal 2019 18:359, 10 November 2019

A major health burden in Cameroon is malaria, a disease that is sensitive to climate, environment and socio-economic conditions, but whose precise relationship with these drivers is still uncertain. An improved understanding of the relationship between the disease and its drivers, and the ability to represent these relationships in dynamic disease models, would allow such models to contribute to health mitigation and adaptation planning. 

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