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TRM cell

NOT Open Access | Harnessing liver-resident memory T cells for protection against malaria

January 31, 2021 - 15:51 -- NOT Open Access
Author(s): 
Fernandez-Ruiz D, de Menezes MN, Holz LE, Ghilas S, Heath WR, Beattie L
Reference: 
Expert Rev Vaccines. 2021 Jan 27

Tissue-resident memory T cells (TRM cells) are powerful mediators of protracted adaptive immunity to infection in peripheral organs. Harnessing TRM cells through vaccination hence promises unprecedented potential for protection against infection. A paramount example of this is malaria, a major infectious disease for which immunity through traditional vaccination strategies remains challenging. Liver TRM cells appear to be highly protective against malaria, and recent developments in our knowledge of the biology of these cells have defined promising, novel strategies for their induction.

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