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CD8(+)

NOT Open Access | Development of Plasmodium-specific liver resident-memory CD8(+) T cells after heat-killed sporozoite immunization in mice

January 27, 2021 - 10:03 -- NOT Open Access
Author(s): 
Ghilas S, Enders MH, May R, Holz L, Fernandez-Ruiz D, Cozijnsen A, Mollard V, Cockburn IA, McFadden GI, Heath WR, Beattie L
Reference: 
Eur J Immunol. 2021 Jan 23

Malaria remains a major cause of mortality in the world, and an efficient vaccine is the best chance of reducing the disease burden. Vaccination strategies for the liver stage of disease that utilise injection of living radiation-attenuated sporozoites (RAS) confer sterile immunity, which is mediated by CD8+ memory T cells, with liver-resident memory T cells (TRM ) being particularly important. We have previously described a TCR transgenic mouse, termed PbT-I, where all CD8+ T cells recognize a specific peptide from Plasmodium. PbT-I form liver TRM cells upon RAS injection and are capable of protecting mice against challenge infection.

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