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neutralizing epitope

Identification of a neutralizing epitope within minor repeat region of Plasmodium falciparum CS protein

January 20, 2021 - 06:14 -- Open Access
Calvo-Calle JM, Mitchell R, Altszuler R, Othoro C, Nardin E
NPJ Vaccines. 2021 Jan 18;6(1):10

Malaria remains a major cause of morbidity and mortality worldwide with 219 million infections and 435,000 deaths predominantly in Africa. The infective Plasmodium sporozoite is the target of a potent humoral immune response that can protect murine, simian and human hosts against challenge by malaria-infected mosquitoes. Early murine studies demonstrated that sporozoites or subunit vaccines based on the sporozoite major surface antigen, the circumsporozoite (CS) protein, elicit antibodies that primarily target the central repeat region of the CS protein.

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