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South East Asia

Not Open Access | Artemisinin inspired synthetic endoperoxide drug candidates: Design, synthesis, and mechanism of action studies

August 10, 2021 - 17:46 -- NOT Open Access
Woodley CM, Amado PSM, Cristiano MLS, O'Neill PM
Med Res Rev. 2021 Aug 6

Artemisinin combination therapies (ACTs) have been used as the first-line treatments against Plasmodium falciparum malaria for decades. Recent advances in chemical proteomics have shed light on the complex mechanism of action of semi-synthetic artemisinin (ARTs), particularly their promiscuous alkylation of parasite proteins via previous heme-mediated bioactivation of the endoperoxide bond. Alarmingly, the rise of resistance to ART in South East Asia and the synthetic limitations of the ART scaffold have pushed the course for the necessity of fully synthetic endoperoxide-based antimalarials.

Plasmodium-a brief introduction to the parasites causing human malaria and their basic biology

January 16, 2021 - 09:54 -- Open Access
Sato S
J Physiol Anthropol. 2021 Jan 7;40(1):1

Malaria is one of the most devastating infectious diseases of humans. It is problematic clinically and economically as it prevails in poorer countries and regions, strongly hindering socioeconomic development. The causative agents of malaria are unicellular protozoan parasites belonging to the genus Plasmodium. These parasites infect not only humans but also other vertebrates, from reptiles and birds to mammals. To date, over 200 species of Plasmodium have been formally described, and each species infects a certain range of hosts.

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