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EIP

A non-destructive sugar-feeding assay for parasite detection and estimating the extrinsic incubation period of Plasmodium falciparum in individual mosquito vectors

May 5, 2021 - 11:25 -- Open Access
Author(s): 
Guissou E, Waite JL, Lefèvre T, et al.
Reference: 
Sci Rep. 2021 Apr 29;11(1):9344

Despite its epidemiological importance, the time Plasmodium parasites take to achieve development in the vector mosquito (the extrinsic incubation period, EIP) remains poorly characterized. A novel non-destructive assay designed to estimate EIP in single mosquitoes, and more broadly to study Plasmodium-Anopheles vectors interactions, is presented.

Estimating the extrinsic incubation period of malaria using a mechanistic model of sporogony

February 17, 2021 - 09:27 -- Open Access
Author(s): 
Stopard IJ, Churcher TS, Lambert B
Reference: 
PLoS Comput Biol. 2021 Feb 16;17(2):e1008658

During sporogony, malaria-causing parasites infect a mosquito, reproduce and migrate to the mosquito salivary glands where they can be transmitted the next time blood feeding occurs. The time required for sporogony, known as the extrinsic incubation period (EIP), is an important determinant of malaria transmission intensity. The EIP is typically estimated as the time for a given percentile, x, of infected mosquitoes to develop salivary gland sporozoites (the infectious parasite life stage), which is denoted by EIPx. Many mechanisms, however, affect the observed sporozoite prevalence including the human-to-mosquito transmission probability and possibly differences in mosquito mortality according to infection status.

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

January 7, 2021 - 09:02 -- Open Access
Author(s): 
Shaw WR, Holmdahl IE, Itoe MA, Werling K, Marquette M, Paton DG, Singh N, Buckee CO, Childs LM, Catteruccia F
Reference: 
PLoS Pathog. 2020 Dec 31;16(12):e1009131

Many mosquito species, including the major malaria vector Anopheles gambiae, naturally undergo multiple reproductive cycles of blood feeding, egg development and egg laying in their lifespan. Such complex mosquito behavior is regularly overlooked when mosquitoes are experimentally infected with malaria parasites, limiting our ability to accurately describe potential effects on transmission.

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