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drug kinetics

NOT Open Access | Malaria-induced Alterations of Drug Kinetics and Metabolism in Rodents and Humans

January 6, 2021 - 12:46 -- NOT Open Access
Author(s): 
De-Oliveira ACAX, Paumgartten FJR
Reference: 
Curr Drug Metab. 2021 Jan 1

Infections and inflammation lead to a downregulation of drug metabolism and kinetics in experimental animals. These changes in the expression and activities of drug-metabolizing enzymes may affect the effectiveness and safety of pharmacotherapy of infections and inflammatory conditions.

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