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Systematic review

NOT Open Access | Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses

July 27, 2020 - 12:31 -- NOT Open Access
Author(s): 
Park S, Nixon CE, Miller O, Choi NK, Kurtis JD, Friedman JF, Michelow IC
Reference: 
J Infect Dis. 2020 Jul 23; 222(4):538-550

Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy.

Pregnancy-specific malarial immunity and risk of malaria in pregnancy and adverse birth outcomes: a systematic review

February 2, 2020 - 17:33 -- Open Access
Author(s): 
Julia C. Cutts, Paul A. Agius, Zaw Lin, Rosanna Powell, Kerryn Moore, Bridget Draper, Julie A. Simpson, Freya J. I. Fowkes
Reference: 
BMC Medicine volume 18:14 (2020)

In endemic areas, pregnant women are highly susceptible to Plasmodium falciparum malaria characterized by the accumulation of parasitized red blood cells (pRBC) in the placenta. In subsequent pregnancies, women develop protective immunity to pregnancy-associated malaria and this has been hypothesized to be due to the acquisition of antibodies to the parasite variant surface antigen VAR2CSA. In this systematic review we provide the first synthesis of the association between antibodies to pregnancy-specific P. falciparum antigens and pregnancy and birth outcomes.

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